宫瑞,博士。现任深圳理工大学(筹)合成生物学院科研助理教授。主要研究方向为生物传感器的开发及应用。1)利用合成生物学与光遗传学相结合,检测细胞内的环境变化及分子过程;2)利用合成生物学、纳米生物学和电化学技术,开发超灵敏体外检测技术,用于病原微生物及其标志物的检测。以第一作者(含共一)和共同通讯作者在J Am Chem Soc,ACS Catalysis,Sci China Life Sci,Chemical Science等高水平学术期刊发表论文7篇。
2024—至今,深圳理工大学(筹),合成生物学院,科研助理教授
2022-2024,深圳市第二人民医院/中国科学院深圳先进技术研究院,博士后
2018-2021,中国科学院生物物理研究所,博士
2014-2018,中国科学院天津工业生物技术研究所,硕士
2010-2014,山东农业大学, 学士
生物传感器的开发及其在疾病研究中的应用;利用合成生物学、蛋白改造和纳米生物学开发肿瘤治疗新策略。
[1]X.Fang#,R.Gong#,D.Yang#,C.Li,Y.Zhang,Y.Wang,G.Nie,M.Li*, X.Peng*, B.Zhang*,NIR-II Light-Driven Genetically Engineered Exosome Nanocatalysts for Efficient Phototherapy against Glioblastoma,Journal of the American Chemical Society,2024 accepted.
[2]R. Gong#,C. Yang#*, G. Abbas, D. Wang, X. Zhang*, G. Nie*, H. Ding*, Diagnosis of nasopharyngeal carcinoma using an ultrasensitive immunoassay method based on nanoparticles,Nanoscale, 2023153475 - 3481.
[3]Z. Li#,R. Gong#*, G. Abbas, X. Feng, X. Wang, J. Wang, H. Huang, J. Han, B. Zhang, G. Nie*, H. Ding*,Dual phase‐conversion strategy reinforced otitis media therapy using metastable iron sulfide‐loaded thermosensitive hydrogel,Advanced Therapeutics,20232300073.
[4]R. Gong#,D. Wang, G. Abbas, S. Li, Q. Liu, M. Cui, X.-E. Zhang*, A switch-on molecular biosensor for detection of caspase-3 and imaging of apoptosis of cells,Science China Life Sciences, 202265540-549.
[5]P. Yao#, P. Cong#,R. Gong#, J. Li, G. Li, J. Ren, J. Feng, J. Lin, P.C.K. Lau, Q. Wu*, D. Zhu*, Biocatalytic Route to Chiral 2-Substituted-1,2,3,4-Tetrahydroquinolines Using Cyclohexylamine Oxidase Muteins,ACS Catalysis, 201881648-1652.
[6]R. Gong#,P. Yao, X. Chen, J. Feng, Q. Wu*, P.C.K. Lau*, D. Zhu*, Accessing d-Valine Synthesis by Improved Variants of Bacterial Cyclohexylamine Oxidase,ChemCatChem, 201810 387-390.
[7] G. Li#, P. Yao#,R. Gong#,J. Li, P. Liu, R. Lonsdale, Q. Wu, J. Lin*, D. Zhu*, M.T. Reetz*, Simultaneous engineering of an enzyme's entrance tunnel and active site: the case of monoamine oxidase MAO-N,Chemical Science201784093-4099.