李翔

教授,

生命健康学院

邮箱:xiang.li@siat.ac.cn

个人简介

李翔,2002年从浙江大学生物医学工程专业毕业,取得了生物医学工程的硕士学位。2007年获得美国凯斯西储大学神经科学博士。从事生物物理和神经生物学的研究,开发了多种调控神经活动的分子工具,同时在离子通道调控机制、神经突触及神经网络可塑性及神经退行性疾病等领域积累了丰富研究经验。2016年起,任中科院深圳先进技术研究院,研究员、教授、博士导师,同时兼任广东省脑图谱联接重点实验室副主任。2021年加入深圳理工大学,科研正教授。主持了国家、省市多个项目。目前聚焦于退行性疾病的分子机制和药物开发。


学习工作经历

学习经历:

09/94—06/99Zhejiang University, China, B.S. in Biomedical Engineering

09/99—06/02Zhejiang University, China, M.S. in Biomedical Engineering

07/02—06/03Case Western Reserve University, Department of Biomedical Engineering

07/03—05/07Case Western Reserve University, Ph.D. in Department of Neuroscience

工作经历:

Postdoctoral Fellow, Department of Neuroscience, Columbia University

Associate Research Scientist, Columbia University

Principal Investigator at BCBDI, SIAT/SUAT


研究领域

1.神经退行性疾病;

2.“骨-脑”调控

3.神经代谢


代表文章

1. Ben Ovryn,Xiang Li, Hille Chiel, Stefan Herlitze. Optical control of a rhodopsin-based switch. Proceeding of International Society of Optical Engineering, 2004, 5324, 197-207.


2.Xiang Li, Alexander Hümmer, Jing Han, Mian Xie, Katya Melnik-Martinez, Rosa L. Moreno, Matthias Buck, Melanie D. Mark, and Stefan Herlitze. G protein beta2 subunit-derived peptides for inhibiton and induction of G protein pathways. The Journal ofBiologicalChemistry, 2005, 280, 23945-23959


3.Xiang Li, Davina V. Gutierrez , M. Gartz Hanson , Jing Han , Melanie D. Mark , Hillel Chiel , Peter Hegemann , Lynn T. Landmesser, and Stefan Herlitze. Fast noninvasive activation and inhibition of neural and network activity by vertebrate rhodopsin and green algae channelrhodopsin. Proc.Natl.Acad.Sci.USA, 2005, 102, 17816-17821


4. Jing Han, Melanie D. Mark,Xiang Li, Mian Xie, Sayumi Waka, Jens Rettig and Stefan Herlitze. RGS2 Determines Short-Term Synaptic Plasticity in Hippocampal Neurons by Regulating G(i/o)- Mediated Inhibition of Presynaptic Ca(2+) Channels. Neuron, 2006, 51(5):575-586


5. Blaine N. Armbruster,Xiang Li, Mark H. Pausch, Stefan Herlitze, and Bryan L. Roth. Evolving the lock to fit the key: using directed molecular evolution to create a family of muscarinic acetylcholine receptors potently activated by an inert ligand. Proc.Natl.Acad.Sci.U S A. 2007 Mar 20; 104(12):5163-8


6.Mian Xie,Xiang Li, Jing Han, Daniel L. Vogt, Silke Wittemann, Melanie D. Mark, and Stefan HerlitzeFacilitation versus depression in cultured hippocampal neurons determined by targeting of Ca2+ channel Cav{beta}4 versus Cav{beta}2 subunits to synaptic terminals.Journal ofCell Biology2007 Jul 30;178(3):489-502


7. Xiaobing Chen, Christine Winters, Rita Azzam,Xiang Li, James Galbraith, Richard D. Leapman, Thomas S. Reese.Organization of the core structure of the postsynaptic density. Proc.Natl.Acad.Sci.U S A 2008 Mar 7


8. Yi-Ping Rong, Ademuyiwa S. Aromolaran, Geert Bultynck, Fei Zhong,Xiang Li, Karen McColl, Stefan Herlitze, Shigemi Matsuyama, H. Llewelyn Roderick, Martin D.Bootman, Gregory A. Mignery, Jan B Parys, Humbert De Smedt, Clark W Distelhorst. Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals. MolecularCell 2008 Jul 25;31(2):255-65


9.Xiaobing Chen, Christine Winters, Rita Azzam,Xiang Li, James Galbraith, Richard D. Leapman, Thomas S. Reese.Identifying individual scaffolding molecules in the postsynaptic density.Microsc Microanal.2008 Aug;14 Suppl 2:1068-9


10. Warren Alilain,Xiang Li, Kevin P. Horn, Rishi Dhingra, Thomas E. Dick, Stefan Herlitze, Jerry Silver. Light induced return of motor function after spinal cord injury through a new type of respiratory plasticity. Journal of Neuroscience, 2008Nov 12;28(46):11862-70


11.Xiaobing Chen, Nelson CD,Xiang Li, James Galbraith, Richard D. Leapman, Gainer H, Sheng M, Thomas S. Reese.PSD-95 Is Required to Sustain the Molecular Organization of the Postsynaptic Density Journal of Neuroscience, 2011Apr 27;31(17):6329-6338


12.Xinzhu Yu, Gordon Wang, Ada Xin Yee,Xiang Li,Tonghui Xu, Stefan Smith, Lu Chen, Yi ZuoAccelerated experience-dependent pruning of cortical synapses in ephrin-A2 knockout mice.Neuron2013 Oct 2;80(1):64-71


13.Xiang Li, Joseph Rayman, Eric Kandel, Irina DerkatchFunctional Role for Tia1/Pub1 and Sup35Prion Domains: Directing Protein SynthesisMachinery to Tubulin Cytoskeleton. Molecular Cell 2014 June 24


14. Luana Fioriti, Cory Myers, Yan-You Huang,Xiang Li, Joseph S Stephan, Pierre Trifilieff, Luca Colnaghi, Stylianos Kosmidis, Bettina Drisaldi, Elias Pavlopoulos, Eric R Kandel Persistence of long term memory storage and its reconsolidation require CPEB3-dependent protein synthesis in the hippocampus. Neuron 2015 June 17 1433-1448


15.Jennifer L. Hodges, Xinzhu Yu, Anthony Gilmore, Hannah Bennett, Michelle Tjia, James F. Perna, Chia-Chien Chen,Xiang Li, Ju Lu, Yi Zuo Astrocytic Contributions to Synaptic and Learning Abnormalities in a Mouse Model of Fragile X Syndrome Biological Psychiatry 2016


16. Zhengjiang Qian, Yanjiao Li, Jidong Chen,Xiang Li, Deming Gou MiR-4632 mediates PDGFBB-induced proliferation and anti-apoptosis of human pulmonary artery smooth muscle cells via targeting cJUNAmerican Journal of Physiology - Cell Physiology 2017July 12


17.Xiaotao Li,Xiang LiThe Antidepressant Effect of Light Therapy from Retinal Projections Neurosci Bull. 2018 Apr;34(2):359-368


18.Zhengjiang Qian, Yanjiao Li,Haiyang Yang,Jidong Chen,Xiang Li, Deming GouPDGFBB promotes proliferation and migration via regulating miR-1181/STAT3 axis in human pulmonary arterial smooth muscle cellsAm J Physiol Lung Cell Mol Physiol. 2018 Sep 13


19.Lei Li, Xiaolong Feng, Zheng Zhou, Huiqi Zhang, Qianqian Shi, Zhuogui Lei, Peilei Shen, Qingning Yang, Binghao Zhao, Shuran Chen, Lin Li, Yulin Zhang, Pengjie Wen, Zhonghua Lu,Xiang Li, Fuqiang Xu, Liping WangStress accelerates defensive responses to looming in mice and involves a locus coeruleus-superior colliculus projectionCurrent Biology, 2018


20.Joseph B. Rayman, Joud Hijazi,Xiang Li, Nancy Kedersha, Paul J. Anderson, and Eric R. KandelGenetic Perturbation of TIA1 Revealsa Physiological Role in Fear MemoryCell Reports 26, 2970–29832019


21.Wei Chen, Hai Lin, Minrui Lyu, Victoria J Wang,Xiang Li, Shixing Bao, Guoping Sun, Jun Xia, Peijun Wang, Alzheimer’s Disease Neuroimaging InitiativeThe potential role of leukoaraiosis in remodeling the brain network to buffer cognitive decline: a Leukoaraiosis And Disability study from Alzheimer’s Disease Neuroimaging InitiativeQuantitative Imaging in Medicine and Surgery2021 Jan; 11(1): 183–203


22.Zhengjiang Qian, Haiyang Yang, Hongchao Li, Chunhua Liu, Liang Yang, Zehui Qu,Xiang LiThe Cholinergic Anti-Inflammatory Pathway Attenuates the Development of Atherosclerosis in Apoe-/-Mice through Modulating Macrophage FunctionsBiomedicines 2021, 9(9), 1150;


23.Yan Liang, Chunhua Liu, Shuxia Yan, Pu Wang, Binbin Wu, Chengzi Jiang, Xiaoqing Li, Yanwen Liu,Xiang LiA novel polysaccharide from plant fermentation extracts and its immunomodulatory activity in macrophage RAW264. 7 cellsFood and Agricultural Immunology 202132, Issue 1


24.Zhengjiang Qian, Hongchao Li, Haiyang Yang, Qin Yang, Zhonghua Lu, Liping Wang, Ying Chen,Xiang LiOsteocalcin attenuates oligodendrocyte differentiation and myelination via GPR37 signaling in the mouse brainScience advances20217 (43)


25.Zhengjiang Qian, Chunhua Liu, Hongchao Li, Haiyang Yang, Jianhao Wu, Jing Liu, Yanjiao Li, Xuhui Chen, Jianyang Xu, andXiang LiOsteocalcin Alleviates Lipopolysaccharide-Induced Acute Inflammation via Activation of GPR37 in Macrophages. Biomedicines, 2022 10(5), 1006.


26. Liang Yang, Junfeng Shen, Chunhua Liu, Zhonghua Kuang, Yong Tang, Zhengjiang Qian, Min Guan, Yongfeng Yang, Yang Zhan, Nan Li,Xiang LiNicotine rebalances NAD+ homeostasis and improves aging-related symptoms in male mice by enhancing NAMPT activity Nat Commun 14, 900 (2023)


27.Yefei Chen, Zexuan Hong, Jingyi Wang, Kunlin Liu, Jing Liu, Jianbang Lin, Shijing Feng, Tianhui Zhang, Liang Shan, Taian Liu, Pinyue Guo, Yunping Lin, Tian Li, Qian Chen, Xiaodan Jiang, Anan Li,Xiang Li, Yuantao Li, Jonathan J Wilde, Jin Bao, Ji Dai, Zhonghua LuCircuit-specific gene therapy reverses core symptoms in a primate Parkinson’s disease modelCell 186, 5394–54102023


28.Danilo Correa Pinto Junior, Isabella Canal Delgado, Haiyang Yang, Alisson Clemenceau, André Corvelo, Giuseppe Narzisi, Rajeeva Musunuri, Julian Meyer Berger, Lauren E Hendricks, Kazuya Tokumura, Na Luo, Hongchao Li, Franck Oury, Patricia Ducy, Vijay K Yadav,Xiang Li, Gerard KarsentyOsteocalcin of maternal and embryonic origins synergize to establish homeostasis in offspringEMBO Rep(2024)25: 593 - 615