王枫，医学博士，中国科学院深圳先进技术研究院脑认知与脑疾病研究所研究员。主要研究方向为“情绪与行为性别差异的神经机制”。综合运用基于机器学习的精细行为分析、神经环路示踪与调控等技术，在科技创新2030—“脑科学与类脑研究”青年科学家项目、国家自然科学基金面上项目等科研基金的支持下重点开展：①本能行为的性别差异性特征及其神经环路机制；②不同脑状态下本能行为变异及其神经机制。已发表SCI收录论文37篇，其中通讯作者（含共同）论文15篇。
学习经历：
2009/09－2012/06，第四军医大学，第一附属医院麻醉科，麻醉学博士，导师：熊利泽
2006/09－2009/06，第四军医大学，第一附属医院麻醉科，麻醉学硕士，导师：熊利泽
2001/09－2006/06，第四军医大学，临床医学学士
工作经历：
2023/10至今，深圳理工大学（筹）、中国科学院深圳先进技术研究院，研究员
2018/03-2022/12，中国科学院深圳先进技术研究院，脑所，副研究员
2013/03-2015/06加拿大渥太华大学精神健康研究中心，博士后
2012/07-2018/03，第四军医大学第一附属医院麻醉科，主治医师，讲师
2009/09-2012/06，第四军医大学第一附属医院麻醉科，医师，助教
深入理解大脑中的性别差异是如何从分子到环路水平协同形成行为的性别差异性特征，是神经科学的主要挑战之一。动物在进化中形成了一系列本能行为，这些行为大都表现出显著的性别二态性；此外，许多神经精神疾病在发病率及发病特征方面也表现出性别差异。因此，课题组的研究集中在综合运用基于机器学习的行为组学、代谢及免疫组学、神经环路示踪与调控等前沿技术：①绘制多状态下两性全生命周期行为图谱；②解析本能行为的性别差异性特征及其神经环路机制；②阐明不同脑状态下本能行为变异及其神经机制。
1.Li XL#, Zhou Y,Wang F*, Wang LP*.Sex-dimorphic kidney-brain connectivity map of mice.Neurosci Bull.2024. Accepted
2.Liu JJ#, Ye JL, Ji CY, Ren WT, He YW, Xu FQ*,Wang F*. Mapping the behavioral signatures ofShank3bmice in both sexes.Neurosci Bull.2024. Accepted
3.Huang HR#,Liu X#,Wang LP,Wang F*.Whole-brain connections of glutamatergic neurons in the mouse lateral habenula in both sexes.Biol Sex Differ.2024 Apr 23;15(1):37.
4.Liu XL#, Zhao GY#, Huang HR, Ye JL, Xu JF, Zhou Y, Zhu XJ, Wang LP,Wang F*.Lifespan changes in cannabinoid 1 receptor mRNA expression in the female C57BL/6J mouse brain.J Comp Neurol.2023;531(2):294-313.
5.Liu X#, Feng XL#, Huang HR#, Huang K, Xu Y, Ye SW, Tseng YT, Wei PF, Wang LP,Wang F*.Male and female mice display consistent lifelong ability to address potential life-threatening cues using different post-threat coping strategies.BMC Biology.2022;20(1):281.
6.Liu X#, Huang HR#, Zhang YL, Wang LP,Wang F*.Sexual dimorphism of inputs to the lateral habenula in mice.Neurosci Bull.2022;38(12):1439-1456.
7.Liu X#, Huang HR#, Terrance S,Cao P, Wang LP,Wang F*.The superior colliculus: cell types, connectivity, and behavior.Neurosci Bull.2022;38(12):1519-1540.
8.ZhangYL#, Ke J#, Zhou Y, Liu X, Huang TW*,Wang F*.Sex-specific characteristics of cells expressing the cannabinoid 1 receptor in the dorsal horn of the lumbar spinal cord.J Comp Neurol.2022;530(14):2451-2473.
9.YangC#, LiuJ#, WangJ, YinA, JiangZ, YeS,Liu X, ZhangX,Wang F*,XiongL*Activation of astroglial CB1R mediates cerebral ischemic tolerance induced by electroacupuncture.J Cereb Blood Flow Metab.2021;41(9):2295-2310.
10.Liu X#, Li X#, Zhao G,Wang F*, Wang LP.Sexual dimorphic distribution of cannabinoid 1 receptor mRNA in adult C57BL/6J mice.J Comp Neurol.2020;528(12):1986-1999.
11.WangF#, HanJ#, HigashimoriH#, Wang J#,LiuJ, TongL, YangY, DongH, ZhangX*, Xiong L*.Long-term depressioninduced by endogenous cannabinoidsproduces neuroprotectionviaastroglial CB1Rafter stroke in rodents.J Cereb Blood Flow Metab.2019;39(6):1122-1137.
12.YinA#,Wang F*, Zhang Xia.Integrating Endocannabinoid Signaling in the Regulation of Anxiety and Depression.Acta Pharmacol Sin.2019;40(3):336-341.
13.Liu X#, Chen C#, Liu Y#, Wang Z, Huang K,Wang F*and Wang LP*.Gentle handling attenuates innate defensive responses to visual threats.FrontBehavNeurosci.2018;12:239.
14.Liu X#, Tian F, Wang S,WangF*, Xiong L*.Astrocyte autophagy flux protects neurons against oxygen-glucose deprivation and ischemic/reperfusion injury.Rejuvenation Res. 2018 Oct;21(5):405-415.
15.CaiY#, Peng Z#, GuoH,WangF*, ZengY*.TREK-1 pathway mediates isoflurane-induced memory impairment in middle-aged mice.Neurobiol Learn Mem.2017;16;145:199-204.
16.Wang F#,Li M#,Li X,Kinden R,Zhou H,Guo F,Wang Q*,Xiong L*.2-Arachidonylglycerol protects primary astrocytes exposed to oxygen-glucose deprivation through a blockade of NDRG2 signaling and STAT3 phosphorylation.Rejuvenation Res. 2016;19:215-22.
17.Wang F#*, Liang W#, Lei C, Kinden R, Sang H, Xie Y, Huang Y, Qu Y, Xiong L*.Combination of HBO and memantine in focal cerebral ischemia: is there a synergistic effect?Mol Neurobiol. 2015;52:1458-66.
18.Wang F#, Zhong H#, Li X, Peng Y, Kinden R, Liang W, Li X, Shi M, Liu L, Wang Q*, Xiong L*.Electroacupuncture attenuates reference memory impairment associated with astrocytic NDRG2 suppression in APP/PS1 transgenic mice.Mol Neurobiol.2014;50:305-13.
19.Wang F#,Gao Z#, Li X, Li Y, Li X, Zhong H, Xu N, Cao F, Wang Q*, Xiong L*.NDRG2 is involved in anti-apoptosis induced by electroacupuncture pretreatment after focal cerebral ischemia in rats.Neurol Res.2013;35:406-414.
20.Wang Q#*,Wang F#, Li X#, Yang Q, Li X, Xu N, Huang Y, Zhang Q, Gou X, Chen S, Xiong L*.Electroacupuncture pretreatment attenuates cerebral ischemic injury through alpha7 nicotinic acetylcholine receptor-mediated inhibition of high-mobility group box 1 release in rats.J Neuroinflammation.2012; 9:24.
