● 研究领域

1. 骨科生物材料设计与3D打印（Design of Orthopedic biomaterials and 3D Printing）

2. 干细胞代谢调控与组织工程（Stem Cell Metabolic Regulation and Tissue Engineering）

3. 骨病发病机理与药物递送（Pathogenesis of Bone Diseases and Drug deliver）

4. 压电材料骨再生应用与医疗成像设备开发与转化（Regenerative Applications of Piezoelectric Materials and Development of Medical Imaging Devices）

● 个人简介

李健，博士毕业于中国科学院大学，现任深圳理工大学医疗器械产业技术研究院特聘副教授、独立PI、硕士研究生导师。课题组长期致力于生物材料与组织再生研究，聚焦于面向大段骨缺损修复的创新生物材料及药物递送诊疗技术的研发与转化。建立了“代谢调控材料‑诊疗技术创新‑病理机制解析”三位一体的特色体系，推动学术理论与临床转化的有机结合。至今以第一/通讯作者在Cell子刊Trends in Biotechnology等期刊发表JCR Q1论文33篇，累计影响因子超290。系统阐释了材料特性调控骨再生代谢的分子机制，首次提出“代谢激活能量材料（MAM）”理论；创新开发了组织工程支架血管化多模态活体定量技术（TPEF/SHG）。参与编著中英文专著2部，从理论、方法到体系层面促进学科发展与临床转化体系建设。

● 学习经历：

2019.09-2022.11，中国科学院大学，博士

2008.09-2011.07，汕头大学，    硕士

2004.09-2008.07，湖北民族大学，  学士

● 工作经历：

2026.1-至今，  深圳理工大学医疗器械产业技术研究院，特聘副教授

2017.12-2025.12，中国科学院深圳先进技术研究院，助理研究员一级。

2015.12-2017.11，中国科学院深圳先进技术研究院，助理研究员二级。

2013.12-2015.11，中国科学院深圳先进技术研究院，助理研究员三级。

2011.07-2013.11，中国科学院深圳先进技术研究院，研究实习员。

● 所获荣誉

2025年 第二十七届中国国际高新技术成果交易会“优秀科研成果创新奖”

2022年 第二十四届中国国际高新技术成果交易会“优秀产品奖证书”

2022年 第二届“率先杯”未来技术创新大赛“优胜奖”

2021年 深圳市创新南山“创业之星”大赛新材料行业赛团队三等奖

● 科研成果

担任国际应用科学与技术协会委员（IAAST）,中国生物材料学会再生医学材料分会委员、国际华人骨研学会终身会员，Journal of Medicine and Health Science副主编；Cell Proliferation、Biofunctional Materials期刊青年编委；Bioengineering、Front Bioeng Biotech等期刊生物材料专刊客座编辑；作为Biomaterials，Materials Today Advances，Acta Biomaterialia、International Immunopharmacology，Phytomedicine，Neuroscience等十余个期刊同行评议审稿人。

● 重大科技项目承担情况：

1. 广东省基础与应用基础研究，面上项目，2026-2028，在研，主持

2. 山东省济南市“海右计划”产业领军人才创新团队项目，2024-2027，在研，核心骨干

3. 深圳市南山区自主创新产业发展专项资金，2021-2022，结题，主持

4. 广东省粤港澳大湾区国际科技创新中心项目，2022-2024，结题，核心骨干

5. 国自然基金委重大研发计划培育项目，2021-2023，结题，核心骨干

6. 深圳医用生物活性材料工程中心提升项目，2019-2021，结题，核心骨干

7. 中国科学院深圳先进院优秀青年创新基金，2016-2018，结题，主持

● 代表性文章：

[1] J. Li*, X. Zhang, Z.X. Peng, J.H. Chen, J.H. Liang, L.Q. Ke, D. Huang, W.X. Cheng, S. Lin, G. Li, R. Hou, W.Z. Zhong, Z.J. Lin, L. Qin, G.Q. Chen, P. Zhang, Metabolically activated energetic materials mediate cellular anabolism for bone regeneration, Trends Biotechnol 42(12) (2024) 1745-1776. (Cell子刊)

[2] J. Chen, J. Tan, N. Wang, H. Li, W. Cheng, J. Li, B. Wang, A.C. Sedgwick, Z. Chen, G. Chen, P. Zhang, W. Zheng, C. Liu, J. Chen, Specific macrophage RhoA targeting CRISPR-Cas9 for mitigating osteoclastogenesis-induced joint damage in inflammatory arthritis, Cell reports Medicine 6(4) (2025) 102046. (Cell子刊)

[3] J. Li, J.N. Chen, Z.X. Peng, N.B. Chen, C.B. Liu, P. Zhang, X. Zhang, G.Q. Chen, Multifunctional Electrospinning Polyhydroxyalkanoate Fibrous Scaffolds with Antibacterial and Angiogenesis Effects for Accelerating Wound Healing, ACS Appl Mater Interfaces 15(1) (2023) 364-377.

[4] X. Zhang#, J. Li#, J. Chen, Z.X. Peng, J.N. Chen, X. Liu, F. Wu, P. Zhang, G.Q. Chen, Enhanced bone regeneration via PHA scaffolds coated with polydopamine-captured BMP2, J Mater Chem B 10(32) (2022) 6214-6227.

[5] J. Li*, X. Zhang, A. Udduttula, Z.S. Fan, J.H. Chen, A.R. Sun, P. Zhang, Microbial-Derived Polyhydroxyalkanoate-Based Scaffolds for Bone Tissue Engineering: Biosynthesis, Properties, and Perspectives, Front Bioeng Biotech 9 (2021).

[6] A. Udduttula#, J. Li#, P.Y. Zhao, G.C. Wang, J.V. Zhang, P.G. Ren, Sol-gel derived nanosized Sr5(PO4)2SiO4 powder with enhanced in vitro osteogenesis and angiogenesis for bone regeneration applications, Ceram Int 45(3) (2019) 3148-3158.

[7] J. Li, Q. Xu, B. Teng, C. Yu, J. Li, L. Song, Y.X. Lai, J. Zhang, W. Zheng, P.G. Ren, Investigation of angiogenesis in bioactive 3-dimensional poly (D, L-lactide-co-glycolide)/nano-hydroxyapatite scaffolds by in vivo multiphoton microscopy in murine calvarial critical bone defect, Acta Biomater 42 (2016) 389-399.

[8] J. Li, L. Xiang, X.T. Jiang, B. Teng, Y.T. Sun, G.L. Chen, J. Chen, J.V. Zhang, P.G. Ren, Investigation of bioeffects of G protein-coupled receptor 1 on bone turnover in male mice, J Orthop Transl 10 (2017) 42-51.

[9] J. Li, H. Jahr, W. Zheng, P.G. Ren, Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair, Jove-J Vis Exp (127) (2017).

[10] J. Li, G.G. Shang, M.L. You, S.W. Peng, Z.H. Wang, H.N. Wu, G.Q. Chen, Endotoxin Removing Method Based on Lipopolysaccharide Binding Protein and Polyhydroxyalkanoate Binding Protein PhaP, Biomacromolecules 12(3) (2011) 602-608.

[11] Z.L. Huang, X.C. He, C.L. Wang, J. Li, L.W. Huang, Y. Zhao, Y.H. Xu, S.W. Gao, L. Peng, Y. Liu, A. Huang, T. Li, Energy Storage Performance Enhanced and High Stability Achieved in BNT-Based Lead-Free Ceramics under Low Electric Field via Domain Engineering, Acs Appl Mater Inter 17(23) (2025) 34255-34265.

[12] X. Dai, L. Liang, C. Wang, J. Li, H. Wan, J. Lin, X. He, L. Peng, K. Wang, Y. Liu, A. Huang, T. Li, Significant enhancement of piezoelectric properties in tetragonal PZN-PT crystals by Tm doping, Ceram Int 51(29) (2025) 60611-60617.

[13] A. Udduttula, J. Li, Z. Ma, B. Teng, J.V. Zhang, A.M.M. Ferreira, P. Gentile, G.C. Wang, X.B. Zhao, P.G. Ren, A novel apatite-inspired Sr-5(PO4)(2)SiO4 plasma-sprayed coating on Ti alloy promoting biomineralization, osteogenesis and angiogenesis, Ceram Int 48(8) (2022) 10979-10989.

[14] A. Udduttula, B. Teng, B.N. Chandrashekar, J. Li, X.F. Yu, C. Liu, R. Shi, C. Cheng, J.V. Zhang, P.G. Ren, Novel Sr-5(PO4)(2)SiO4-graphene nanocomposites for applications in bone regeneration in vitro, Appl Surf Sci 507 (2020).

[15] A.R. Sun, A. Udduttula, J. Li, Y.Z. Liu, P.G. Ren, P. Zhang, Cartilage tissue engineering for obesity-induced osteoarthritis: Physiology, challenges, and future prospects, J Orthop Transl 26 (2021) 3-15.

[16] J. Lin, A.R. Sun, J. Li, T. Yuan, W. Cheng, L. Ke, J. Chen, W. Sun, S. Mi, P. Zhang, A Three-Dimensional Co-Culture Model for Rheumatoid Arthritis Pannus Tissue, Front Bioeng Biotechnol 9 (2021) 764212.

[17] B. Teng, C. Huang, C.L. Cheng, A. Udduttula, X.F. Yu, C. Liu, J. Li, Z.Y. Yao, J. Long, L.F. Miao, C. Zou, J. Chu, J.V. Zhang, P.G. Ren, Newly identified peptide hormone inhibits intestinal fat absorption and improves NAFLD through its receptor GPRC6A, J Hepatol 73(2) (2020) 383-393.

[18] J.H. Chen, W.X. Cheng, J. Li, Y. Wang, J.Q. Chen, X. Shen, A.L. Su, D.H. Gan, L.Q. Ke, G. Liu, J.T. Lin, L. Li, X.L. Bai, P. Zhang, Notch-1 and Notch-3 Mediate Hypoxia-Induced Activation of Synovial Fibroblasts in Rheumatoid Arthritis, Arthritis Rheumatol 73(10) (2021) 1810-1819.

[19] J. Chen, J. Tan, J. Li, W. Cheng, L. Ke, A. Wang, Q. Wang, S. Lin, G. Li, B. Wang, J. Chen, P. Zhang, Genetically Engineered Biomimetic Nanoparticles for Targeted Delivery of mRNA to Treat Rheumatoid Arthritis, Small methods (2023) e2300678.

[20] J. Chen, J. Li, J. Chen, W. Cheng, J. Lin, L. Ke, G. Liu, X. Bai, P. Zhang, Treatment of collagen-induced arthritis rat model by using Notch signalling inhibitor, J Orthop Translat 28 (2021) 100-107.

[21] J. Chen, J. Chen, J. Tan, J. Li, W. Cheng, L. Ke, Q. Wang, A. Wang, S. Lin, G. Li, P. Zhang, B. Wang, HIF-1α dependent RhoA as a novel therapeutic target to regulate rheumatoid arthritis fibroblast-like synoviocytes migration in vitro and in vivo, J Orthop Translat 40 (2023) 49-57.

专著

1. 可降解金属，科学出版社，2016年11月, ISBN978-7-03-050393-0.

2. Polyhydroxyalkanoates (PHAs) as Biomaterials for the Regeneration of Bone Tissue. In V. C. Kalia (Ed.), Polyhydroxyalkanoates: Sustainable Production and Biotechnological Applications III (pp. 60–83). Spring Nature, 2025，ISBN 978-981-96-2022-7.

● 代表性专利：

李健；张鹏；彭子欣；一种促血管化组织再生的支架材料及其制备方法；CN202511077027.5.

Li Jian；Zhang Peng; Bioenergetic-active material and use thereof; US18/574727

李健；张鹏；一种生物能量活性材料及其应用; CN202280004789.0.

张鹏; 李健; 白雪岭; 成文翔; 王新峦; 赖毓霄; 镁锶-磷酸硅盐材料及制备方法、包含其的结构可控的多孔骨修复复合支架材料, 2022-3-15, 中国, ZL201911060768.7.

课题组共计申请专利15项，授权11项，包括美国专利2项，专利技术转化2项，企业融资2000万。