王天一，现任深圳理工大学生物医学工程学院教研助理教授、特聘副教授、博士生导师、独立PI。2023年博士毕业于香港大学，2023-2026年于中山大学肿瘤防治中心从事肿瘤生物学、纳米医学及临床转化相关研究工作。主要研究方向为肿瘤免疫代谢、智能纳米药物递送和光响应精准治疗，重点关注肿瘤微环境中的代谢应激、细胞间通讯与免疫调控机制，并发展可控、靶向和刺激响应型纳米递送体系用于精准抗肿瘤治疗。近年来围绕氨基酸饥饿、细胞外囊泡信号、Nano-PROTAC、光控药物递送、光药理学和肿瘤免疫治疗等方向开展研究。以第一作者/通讯作者在Signal Transduction and Targeted Therapy、Chemical Society Reviews、Advanced Science、Nano Today、iScience 等期刊发表论文多篇。

学习经历

2019-2023，香港大学，纳米医学，博士

2013-2018，吉林大学，放射医学，学士

科研与学术工作经历

2026至今，深圳理工大学，生物医学工程学院，教研助理教授、特聘副教授、独立PI

2023至2026，中山大学肿瘤防治中心，助理研究员、临床医师

方向一：肿瘤免疫代谢与代谢应激调控

聚焦肿瘤微环境中营养缺乏、代谢重编程和细胞间通讯对抗肿瘤免疫的影响，研究氨基酸饥饿、谷氨酰胺/氨代谢、CD8+T细胞功能障碍、肿瘤-免疫细胞代谢互作及胞外囊泡介导的免疫微环境重塑机制。

方向二：智能纳米药物递送与肿瘤靶向治疗

围绕肿瘤精准治疗需求，发展响应型、仿生型和细胞选择性纳米递送体系，包括工程化胞外囊泡、脂质纳米颗粒、脂质体、聚合物囊泡和Nano-PROTAC等，用于RNA、蛋白和小分子药物的高效递送及免疫调控。

方向三：光响应纳米医学与时空精准治疗

利用光作为外源性调控手段，实现药物活性、释放行为和细胞信号通路的时空控制，发展光药理学、光动力治疗、免疫治疗联合策略及可控纳米治疗平台，提升肿瘤治疗的精准性和安全性。

(1)Tianyi Wang#, Jieyi Lin#, Xinlei Ai#, Yuchen Li, Ziyao Zhang, Siyi Xie, Yu Chen, Jie Chen, Hui Cheng, Liting Liu, Li Yuan, Liangji Li, Linquan Tang*, Weiping Wang*, Qiuyan Chen*, Haiqiang Mai*, Amino acid-starved cancer cells boost chemokine-containing extracellular vesicles to reshape tumor immune microenvironment, Signal Transduction and Targeted Therapy, Accepted.

(2) Yuwei Liu#,Tianyi Wang#, Weiping Wang*, Photopharmacology and photoresponsive drug delivery, Chemical Society Reviews, 2025.

(3)Tianyi Wang#, Yaming Zhang#, Yuwei Liu, Lichao Wang, Lijun Liu, Weiping Wang*, Optochemical control of G1 cell cycle by regulating CDK4/6 degradation, iScience, 2025.

(4) Shuting Xu, Kaiqi Long,Tianyi Wang, Yangyang Zhu, Yunjiao Zhang, Weiping Wang*, Opto-Epigenetic Regulation of Histone Arginine Asymmetric Dimethylation via Type I Protein Arginine Methyltransferase Inhibition, Journal of Medicinal Chemistry, 2025.

(5) Jinzhao Liu, Qingyang Lyu, Meicen Wu, Yang Zhou,Tianyi Wang, Yichi Zhang, Ni Fan, Chang Yang, Weiping Wang*, Integrating mTOR Inhibition and Photodynamic Therapy Based on Carrier-Free Nanodrugs for Breast Cancer Immunotherapy, Advanced Healthcare Materials, 2024.

(6) Yuwei Liu, Kaiqi Long,Tianyi Wang, Yaming Zhang, Jianping Lei, Weiping Wang*, Sequential light irradiation-controlled cancer stemness inhibition for sensitized photothermal therapy, Nano Today, 2024.

(7) Jie Chen*, Hui Cheng, Yujing Liang, Jieyi Lin, Guodong Jia,Tianyi Wang, Yifu Li, Yu Chen, Pan Wang, Bowen Shen, Sailan Liu, Shanshan Guo, Qiuyan Chen, Linquan Tang, Haiqiang Mai, Liting Liu*, The efficacy of adjuvant chemotherapy in patients with different midpoint-radiotherapy Epstein-Barr virus DNA plasma loads, Oral Oncology, 2024.

(8) Yaming Zhang, Lu Liu,Tianyi Wang, Cong Mao, Pengfei Shan, Chak Sing Lau, Zhongyu Li*, Weisheng Guo*, Weiping Wang*, Reactive oxygen species-responsive polymeric prodrug nanoparticles for selective and effective treatment of inflammatory diseases, Advanced Healthcare Materials, 2023.

(9)Tianyi Wang#, Yaming Zhang#, Yuwei Liu, Yi Huang, Weiping Wang*, Amino Acid-Starved Cancer Cells Utilize Macropinocytosis and Ubiquitin-Proteasome System for Nutrient Acquisition, Advanced Science, 2023.

(10)Tianyi Wang#, Yaming Zhang#, Kang Chen, Yi Huang, Yuwei Liu, Shuting Xu, Weiping Wang*, CDK4/6 nano-PROTAC enhances mitochondria-dependent photodynamic therapy and anti-tumor immunity, Nano Today, 2023.

(11) Yuwei Liu, Kaiqi Long,Tianyi Wang, Weirong Kang, Weiping Wang*, Carrier-free nanodrugs for stemness inhibition-enhanced photodynamic therapy, Aggregate, 2023.

(12) Yuwei Liu, Kaiqi Long, Weirong Kang,Tianyi Wang, Weiping Wang*, Optochemical Control of Immune Checkpoint Blockade via Light-Triggered PD-L1 Dimerization, Advanced NanoBiomed Research, 2022.

(13)Tianyi Wang, Kaiqi Long, Yang Zhou, Xiaoding Jiang, Jinzhao Liu, John H.C. Fong, Alan S.L. Wong, Wai-Lung Ng, Weiping Wang*, Optochemical Control of mTOR Signaling and mTOR-Dependent Autophagy, ACS Pharmacology & Translational Science, 2022.

(14) Yafei Li, Wen Lv, Lang Wang, Yaming Zhang, Lipeng Yang,Tianyi Wang, Linyong Zhu, Yufeng Wang, Weiping Wang*, Photo-triggered nucleus targeting for cancer drug delivery, Nano Research, 2021.

(15) Yafei Li, Yang Zhou,Tianyi Wang, Kaiqi Long, Yaming Zhang, Weiping Wang*, Photoenhanced cytosolic protein delivery based on a photocleavable group-modified dendrimer, Nanoscale, 2021.

(16)Tianyi Wang#, Conghe Liu#, Lili Jia, Jun Ding*, The association between apelin polymorphisms and hypertension in China: A meta-analysis, Journal of the Renin-Angiotensin-Aldosterone System, 2019.

(17)Tianyi Wang, Conghe Liu, Lili Jia*, The roles of PKCs in regulating autophagy, Journal of Cancer Research and Clinical Oncology, 2018.

(18) Yizhi Pan#,Tianyi Wang#, Yanfang Li, Tianwang Guan, Yanxian Lai, Yan Shen, Abudurexiti Zeyaweiding, Tutiguli Maimaiti, Fang Li, Haiyan Zhao, Cheng Liu*, Association of ACE2 polymorphisms with susceptibility to essential hypertension and dyslipidemia in Xinjiang, China, Lipids in Health and Disease, 2018.

(1)国家自然科学基金青年科学基金项目，82503280，2026.1-2028.12，主持

(2)广东省基础与应用基础研究基金面上项目，2026A1515010832，2026.1-2028.12，主持

(3)中国博士后科学基金面上项目，2024M763792，2025.1-2026.8，主持

(4)广东省医学科学技术研究基金项目，A2025003，2025.7-2027.6，主持

专利

(1)王天一；艾馨蕾；肿瘤细胞外泌体、抗肿瘤免疫药物递送系统及其制备方法和应用，CN Patent，No. 202411852296.X，2025.

(2)汪卫平；王天一；一种通过耗竭细胞内氨基酸用于肿瘤治疗的聚合物囊泡纳米颗粒及其方法，US Provisional Patent，No. 63/514,949，2023.

(3)汪卫平；王天一；龙凯麒；一种光化学调控mTOR信号通路及mTOR依赖性自噬的组合物与方法；CN Patent，No. 202210749138.6，2022；US Patent，No. 17/850,720，2022.